Aripiprazole Solution

Pronunciation: AR-i-PIP-ra-zole
Generic Name: Aripiprazole
Brand Name: Abilify

Aripiprazole Solution is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Aripiprazole Solution is not approved to treat mental problems caused by dementia.

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Aripiprazole Solution outweigh the risks.

Families and caregivers must closely watch patients who take Aripiprazole Solution. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Aripiprazole Solution is used for:

Treating schizophrenia, bipolar disorder, and irritability associated with autistic disorder. It is also used along with other medicines to treat depression. It may also be used for other conditions as determined by your doctor.

Aripiprazole Solution is an atypical antipsychotic. Exactly how it works is not known. It affects certain substances in the brain.

Do NOT use Aripiprazole Solution if:

• you are allergic to any ingredient in Aripiprazole Solution

Contact your doctor or health care provider right away if this applies to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Aripiprazole Solution:

Some medical conditions may interact with Aripiprazole Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems (eg, heart failure, irregular heartbeat, heart attack), low blood pressure, blood vessel problems, or stroke


• if you have a history of low white blood cell levels, including low white blood cell levels caused by any medicine


• if you have a history of seizures, dementia, Alzheimer disease, depression or other mental or mood disorders, or suicidal thoughts or attempts


• if you have trouble swallowing or a history of neuroleptic malignant syndrome (NMS)


• if you are dehydrated, have low blood volume, or are taking medicine for high blood pressure


• if you or a family member has a history of diabetes or you are very overweight

Some MEDICINES MAY INTERACT with Aripiprazole Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine, methscopolamine) because the risk of overheating may be increased


• Benzodiazepines (eg, lorazepam), clarithromycin, imidazole antifungals (eg, ketoconazole), quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or voriconazole because they may increase the risk of Aripiprazole Solution's side effects


• Carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease Aripiprazole Solution's effectiveness


• Alpha-blockers (eg, terazosin) because the risk of their side effects may be increased by Aripiprazole Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aripiprazole Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aripiprazole Solution:

Use Aripiprazole Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aripiprazole Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Aripiprazole Solution refilled.


• Take Aripiprazole Solution by mouth with or without food.


• Taking Aripiprazole Solution at the same time each day will help you remember to take it.


• Take Aripiprazole Solution on a regular schedule to get the most benefit from it.


• Use the measuring cup that comes with Aripiprazole Solution to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Continue to take Aripiprazole Solution even if you feel well. Do not miss any doses.


• If you miss a dose of Aripiprazole Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aripiprazole Solution.

Important safety information:

• Aripiprazole Solution may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Aripiprazole Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol while you are using Aripiprazole Solution.


• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Aripiprazole Solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Aripiprazole Solution may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Children, teenagers, and young adults who take Aripiprazole Solution may be at increased risk for suicidal thoughts or actions. Watch all patients who take Aripiprazole Solution closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or unusual changes in mood or behavior, occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Aripiprazole Solution. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Some patients who take Aripiprazole Solution may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Aripiprazole Solution in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Aripiprazole Solution.


• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.


• Aripiprazole Solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Aripiprazole Solution may raise your blood sugar or increase your risk of developing diabetes. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Aripiprazole Solution may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including fasting blood sugar levels and complete blood cell counts, may be performed while you use Aripiprazole Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Aripiprazole Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially uncontrolled muscle movements or seizures.


• Aripiprazole Solution should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Aripiprazole Solution can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aripiprazole Solution while you are pregnant. Using Aripiprazole Solution during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. It is not known if Aripiprazole Solution is found in breast milk. Do not breast-feed while taking Aripiprazole Solution.

Possible side effects of Aripiprazole Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal dreams; blurred vision; constipation; dizziness; drowsiness; headache; increased appetite (in children); increased saliva production; lightheadedness; nausea; sore throat (in children); stomach upset; tiredness; trouble sleeping; vomiting; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; increased sweating; involuntary movements of the tongue, face, mouth, jaw, arms, legs, or back (eg, chewing movements, puckering of mouth, puffing of cheeks); loss of control over urination; loss of coordination; muscle tremor, jerking, or stiffness; new or worsening mental or mood problems (eg, anxiety, depression, agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); one-sided weakness; seizures; severe or persistent restlessness; shortness of breath; suicidal thoughts or attempts; swelling of the hands, ankles, or feet; symptoms of high blood sugar (eg, increased thirst, urination, or appetite; unusual weakness); trouble swallowing; trouble walking; unusual bruising; unusual tiredness or weakness; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aripiprazole side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include aggression; confusion; fast, slow, or irregular heartbeat; loss of consciousness; seizures; severe drowsiness, dizziness, or vomiting; tremor; trouble breathing; unusual mental changes.

Proper storage of Aripiprazole Solution:

Store Aripiprazole Solution at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Throw away any unused medicine after the bottle has been open for 6 months. Throw away any unused medicine after the expiration date on the bottle has passed. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aripiprazole Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Aripiprazole Solution, please talk with your doctor, pharmacist, or other health care provider.


• Aripiprazole Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Aripiprazole Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aripiprazole resources

• Aripiprazole Side Effects (in more detail)
• Aripiprazole Use in Pregnancy & Breastfeeding
• Aripiprazole Drug Interactions
• Aripiprazole Support Group
• 211 Reviews for Aripiprazole - Add your own review/rating

Compare Aripiprazole with other medications

• Agitated State
• Autism
• Bipolar Disorder
• Borderline Personality Disorder
• Depression
• Obsessive Compulsive Disorder
• Post Traumatic Stress Disorder
• Schizoaffective Disorder
• Schizophrenia
• Tourette's Syndrome

Garamycin

Generic Name: gentamicin (gen tah MY sin)

Brand Names: Garamycin

What is Garamycin (gentamicin)?

Gentamicin is an antibiotic. It fights bacteria in the body.

Gentamicin is used to treat severe or serious bacterial infections.

Gentamicin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Garamycin (gentamicin)?

If you are injecting gentamicin at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.

Gentamicin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.

What should I discuss with my healthcare provider before using Garamycin (gentamicin)?

Do not use gentamicin without first talking to your doctor if you have

• 
  

  sulfite sensitivity;

  
  


• kidney disease;


• 
  

  hearing loss or loss of balance due to ear problems;

  
  


• 
  

  Parkinson's disease; or

  
  


• 
  

  a neuromuscular disorder such as myasthenia gravis.

  
  

You may not be able to use gentamicin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not use gentamicin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Do not use gentamicin without first talking to your doctor if you are breast-feeding a baby.

How should I take Garamycin (gentamicin)?

If you are injecting gentamicin at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.

Do not use any gentamicin that is discolored, has particles in it, or looks different from your previous doses. Throw away any unused gentamicin after the amount of time determined by your pharmacist or doctor.

Adequate hydration is important during treatment with gentamicin. Fluids may be administered intravenously during treatment.

It is important that the medication be given on a regular schedule and for the entire amount of time prescribed by your doctor.

Gentamicin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.

Dispose of used needles and syringes in a puncture resistant container out of the reach of children.

Your healthcare provider will store gentamicin as directed by the manufacturer or give you detailed storage instructions if you are storing the medication at home.

What happens if I miss a dose?

Contact your doctor if a dose is missed.

What happens if I overdose?

Contact your doctor or seek emergency medical attention if an overdose is suspected. An overdose of the medication may result in damage to the kidneys or hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures (which may be signs of nerve damage).

What should I avoid while taking Garamycin (gentamicin)?

There are no restrictions on food, beverages, or activity while taking gentamicin unless otherwise directed by your doctor.

Garamycin (gentamicin) side effects

If you experience any of the following serious side effects, stop taking gentamicin and seek emergency medical attention:

• 
  

  an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);

  
  


• 
  

  little or no urine;

  
  


• 
  

  decreased hearing or ringing in the ears;

  
  


• 
  

  dizziness, clumsiness, or unsteadiness;

  
  


• 
  

  numbness, skin tingling, muscle twitching, or seizures; or

  
  


• 
  

  severe watery diarrhea and abdominal cramps.

  
  

Other, less serious side effects may be more likely to occur. Continue to take gentamicin and talk to your doctor if you experience

• 
  

  increased thirst;

  
  


• 
  

  loss of appetite;

  
  


• 
  

  nausea or vomiting;

  
  


• 
  

  a rash.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Garamycin (gentamicin)?

Other drugs, especially those that affect the kidneys, can interact with gentamicin resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with gentamicin.

More Garamycin resources

• Garamycin Side Effects (in more detail)
• Garamycin Use in Pregnancy & Breastfeeding
• Garamycin Drug Interactions
• Garamycin Support Group
• 0 Reviews for Garamycin - Add your own review/rating

• Garamycin Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Garamycin Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Gentamicin Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Gentamicin Professional Patient Advice (Wolters Kluwer)


• Gentamicin Sulfate Monograph (AHFS DI)

Compare Garamycin with other medications

• Bacteremia
• Bacterial Endocarditis Prevention
• Bacterial Infection
• Bone infection
• Brucellosis
• Burns, External
• Cystic Fibrosis
• Endocarditis
• Endometritis
• Febrile Neutropenia
• Intraabdominal Infection
• Kidney Infections
• Meningitis
• Pelvic Inflammatory Disease
• Peritonitis
• Plague
• Pneumonia
• Rabbit Fever
• Skin Infection
• Surgical Prophylaxis

Where can I get more information?

• Your pharmacist has additional information about gentamicin written for health professionals that you may read.

See also: Garamycin side effects (in more detail)

Trizivir

Pronunciation: a-BAK-a-vir/la-MIV-ue-deen/zye-DOE-vue-deen
Generic Name: Abacavir/Lamivudine/Zidovudine
Brand Name: Trizivir

Severe allergic reactions (achiness, cough, diarrhea, difficulty breathing, fever, nausea, rash, sore throat, stomach pain, tiredness, vomiting) have been associated with the use of abacavir. Stop using Trizivir and talk with your health care provider if any of these symptoms occur. Do not restart Trizivir if symptoms of a severe allergic reaction occur. Severe allergic reactions, including death, have occurred in patients who restart Trizivir, even if they have no history or unrecognized symptoms of an allergic reaction. Do not stop and restart Trizivir unless directed to do so by your doctor.

Patients who have a certain gene type called HLA-B^*5701 have an increased risk of an allergic reaction to abacavir. A lab test may be performed before you start Trizivir to see if you have this gene type. Discuss any questions or concerns with your doctor.

Zidovudine has been associated with certain blood disorders (eg, anemia, neutropenia), especially in patients with advanced HIV disease. Muscle disease, high levels of lactic acid in the blood, and severe liver problems that can cause death have also been associated with the use of Trizivir. Tell your doctor immediately if you have dark urine; fever; persistent sore throat; rapid breathing; unusual nausea, tiredness, or weakness; or yellowing of the eyes and skin. Severe worsening of hepatitis B has been reported in patients who are infected with both HIV and hepatitis B and have discontinued lamivudine. Liver function should be monitored closely for at least several months after discontinuing lamivudine. The long-term effects of Trizivir are not known at this time.

Trizivir is used for:

Treating HIV infection. Trizivir is used alone or in combination with other medicines.

Trizivir is a nucleoside reverse transcriptase inhibitor (NRTI) combination. It works by blocking HIV from reproducing.

Do NOT use Trizivir if:

• you are allergic to any ingredient in Trizivir


• you weigh less than 90 pounds


• you have liver problems or the blood disorder lactic acidosis


• you are taking emtricitabine, zalcitabine, or any medicine containing abacavir, lamivudine, or zidovudine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trizivir:

Some medical conditions may interact with Trizivir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney problems, heart problems (eg, heart attack), high blood pressure, high cholesterol, diabetes, pancreatitis, blood or bone marrow disorders, muscle disorders, smoking, alcohol dependence, hepatitis B infection, breathing difficulties, nerve disorders, obesity problems, or a weakened immune system


• if you have abdominal pain, diarrhea, nausea, vomiting, cough, sore throat, fever, fatigue, or a rash


• if you are taking any other medicine for HIV infection


• if you have been tested and know whether or not you have a gene type called HLA-B^*5701

Some MEDICINES MAY INTERACT with Trizivir. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Bone marrow suppressors (eg, interferon alpha), cytotoxic agents (eg, cyclophosphamide), ganciclovir, probenecid, trimethoprim/sulfamethoxazole (TMP-SMZ), or valproic acid because they may increase the risk of Trizivir's side effects


• Doxorubicin, ribavirin, stavudine, or zalcitabine because the effectiveness of both medicines may be decreased


• Clarithromycin because it may decrease Trizivir's effectiveness


• Methadone because its effectiveness may be decreased by Trizivir

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trizivir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trizivir:

Use Trizivir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Trizivir comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Trizivir refilled.


• Take Trizivir by mouth with or without food.


• Taking Trizivir at the same time each day will help you remember to take it.


• Continue to take Trizivir even if you feel well. Do not miss any doses.


• If you miss a dose of Trizivir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than one dose of Trizivir, contact your doctor.

Ask your health care provider any questions you may have about how to use Trizivir.

Important safety information:

• Trizivir may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Trizivir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Trizivir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Trizivir, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Trizivir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Trizivir contains abacavir, lamivudine, and zidovudine. Before you start any new medicine, check the label to see if it has abacavir, lamivudine, or zidovudine in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Carry an ID card at all times that says you take Trizivir.


• Trizivir may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Trizivir.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Trizivir. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• Diabetes patients - Trizivir may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Patients who have a certain gene type called HLA-B^*5701 have an increased risk of a severe or even fatal allergic reaction to Trizivir. A lab test may be performed before you start Trizivir to see if you have this gene type. Discuss any questions or concerns with your doctor.


• Lab tests, including complete blood cell counts and liver function tests, may be performed while you use Trizivir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Trizivir should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Trizivir while you are pregnant. Trizivir is found in breast milk. Do not breast-feed while taking Trizivir. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Trizivir to the baby.

Possible side effects of Trizivir:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased appetite; diarrhea; headache; joint or muscle pain; nausea; nervousness; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (fever; rash; tiredness; achiness; nausea; diarrhea; vomiting; stomach pain; sore throat; hives; itching; difficulty breathing; cough; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; depression; excess hunger, thirst, or urination; fainting; fast, shallow breathing; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mouth ulcers; numbness, tingling, or pain in the hands and feet; pale stools; red, swollen, blistered, or peeling skin; severe or persistent muscle pain, weakness, or cramping; swollen lymph nodes; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Trizivir side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dizziness; drowsiness; headache; nausea; seizures; tiredness; vomiting.

Proper storage of Trizivir:

Store Trizivir at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trizivir out of the reach of children and away from pets.

General information:

• If you have any questions about Trizivir, please talk with your doctor, pharmacist, or other health care provider.


• Trizivir is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Trizivir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Trizivir resources

• Trizivir Side Effects (in more detail)
• Trizivir Use in Pregnancy & Breastfeeding
• Drug Images
• Trizivir Drug Interactions
• Trizivir Support Group
• 0 Reviews for Trizivir - Add your own review/rating

• Trizivir Prescribing Information (FDA)


• Trizivir Advanced Consumer (Micromedex) - Includes Dosage Information


• Trizivir Consumer Overview

Compare Trizivir with other medications

• HIV Infection
• Nonoccupational Exposure

Etravirine

Pronunciation: E-tra-VIR-een
Generic Name: Etravirine
Brand Name: Intelence

Etravirine is used for:

Treating HIV infection in certain patients. It is used in combination with other medicines.

Etravirine is a nonnucleoside reverse transcriptase inhibitor (NNRTI). It works by blocking the growth of HIV.

Do NOT use Etravirine if:

• you are allergic to any ingredient in Etravirine


• you are taking another NNRTI (eg, efavirenz)


• you are taking certain protease inhibitors (eg, indinavir) without ritonavir


• you are taking delavirdine, certain doses of ritonavir, or certain protease inhibitor and ritonavir combinations (eg, tipranavir/ritonavir, atazanavir/ritonavir)


• you are taking a barbiturate (eg, phenobarbital), carbamazepine, a hydantoin (eg, phenytoin), rifampin, rifapentine, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Before using Etravirine:

Some medical conditions may interact with Etravirine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are of childbearing age


• if you have a history of liver problems (eg, hepatitis), diabetes, or high blood cholesterol

Some MEDICINES MAY INTERACT with Etravirine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Delavirdine because it may increase the risk of Etravirine's side effects


• Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), other NNRTIs (eg, efavirenz), protease inhibitor and ritonavir combinations (eg, tipranavir/ritonavir), protease inhibitors (eg, indinavir), rifamycins (eg, rifampin, rifapentine), certain doses of ritonavir, or St. John's wort because they may decrease Etravirine's effectiveness


• Atazanavir/ritonavir because its effectiveness may be decreased by Etravirine and it may increase the risk of Etravirine's side effects


• Fosamprenavir/ritonavir because the risk of its side effects may be increased by Etravirine


• Many prescription and nonprescription medicines (eg, used for anxiety, erectile problems, irregular heartbeat, other heart problems, bacterial infections, fungal infections, immune suppression, inflammation, aches and pains, high cholesterol, HIV, narcotic or other substance dependence and withdrawal, seizures, thinning the blood), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Etravirine. This may decrease their effectiveness, increase the risk of their side effects, decrease Etravirine's effectiveness, or increase the risk of the medicine's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Etravirine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Etravirine:

Use Etravirine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Etravirine. Talk to your pharmacist if you have questions about this information.


• Take Etravirine by mouth following a meal.


• Swallow Etravirine whole with a liquid such as water. Do not chew before swallowing. If you cannot swallow the tablet whole, you may mix it in a glass of water. Stir well until the water looks milky, and then drink all of the liquid right away. Rinse the glass with water several times and completely swallow the rinse each time to ensure the entire dose is taken. Do not store the mixture for future use.


• Taking Etravirine at the same time each day will help you remember to take it.


• Continue to use Etravirine even if you feel well. Do not miss any doses.


• If you miss a dose of Etravirine by less than 6 hours, take the missed dose as soon as possible following a meal, then go back to your regular dosing schedule. If you miss your dose by more than 6 hours, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Etravirine.

Important safety information:

• Etravirine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Etravirine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not change your dose or stop taking Etravirine without talking to your doctor first.


• Etravirine is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Etravirine, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Etravirine does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Etravirine. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• Etravirine may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Etravirine.


• Etravirine may cause serious, potentially life-threatening, and fatal skin reactions. The risk may be greater in women. Symptoms may include red, swollen, blistered, or peeling skin; severe rash or rash with fever, mouth sores, red and irritated eyes, or swelling of the face; muscle or joint pain; unusual tiredness; or unusual hoarseness. These reactions can sometimes be associated with organ failure (eg, liver failure). Contact your doctor at once if you develop a rash or any of these symptoms.


• Lab tests, including liver function, CD4 count, complete blood cell counts, and blood cholesterol, may be performed while you use Etravirine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Etravirine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Etravirine while you are pregnant. It is not known if Etravirine is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing HIV infection or Etravirine to the baby.

Possible side effects of Etravirine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild burning, numbness, or tingling of the arms, hands, legs, or feet.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the eyes, mouth, face, lips, throat, or tongue; unusual hoarseness); bloody vomit or vomit that looks like coffee grounds; blurred vision or other vision changes; change in amount of urine; chest, jaw, or left arm pain; dark urine; fainting; fever or general feeling of being unwell; irregular heartbeat; joint pain; loss of appetite; mood or mental changes (eg, anxiety, confusion, memory loss); muscle pain, tenderness, or weakness; pale stools; persistent burning, numbness, pain, or tingling of the arms, legs, hands, or feet; reddened, blistered, swollen, or peeling skin; seizures; severe or persistent dizziness, drowsiness, or headache; severe rash or rash with fever, mouth sores, or red and irritated eyes; severe stomach pain with or without nausea and vomiting; shortness of breath; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Etravirine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Etravirine:

Store Etravirine between 59 and 86 degrees F (15 and 30 degrees C). Store in original bottle, away from heat, moisture, and light. Do not remove the desiccant pouches from the bottle. Do not store in the bathroom. Keep Etravirine out of the reach of children and away from pets.

General information:

• If you have any questions about Etravirine, please talk with your doctor, pharmacist, or other health care provider.


• Etravirine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Etravirine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Etravirine resources

• Etravirine Side Effects (in more detail)
• Etravirine Use in Pregnancy & Breastfeeding
• Etravirine Drug Interactions
• Etravirine Support Group
• 0 Reviews for Etravirine - Add your own review/rating

• Etravirine Professional Patient Advice (Wolters Kluwer)


• Etravirine Monograph (AHFS DI)


• etravirine Advanced Consumer (Micromedex) - Includes Dosage Information


• Intelence Prescribing Information (FDA)


• Intelence Consumer Overview

Compare Etravirine with other medications

• HIV Infection

Metrogel

1. Name Of The Medicinal Product

Metrogel

2. Qualitative And Quantitative Composition

Metronidazole BP 0.75%.

3. Pharmaceutical Form

Aqueous gel for cutaneous use.

4. Clinical Particulars

4.1 Therapeutic Indications

For the treatment of acute inflammatory exacerbation of rosacea.

For the deodorisation of the smell associated with malodorous fungating tumours.

4.2 Posology And Method Of Administration

For the treatment of rosacea:

For topical administration only.

The average period of treatment is three to four months. The recommended duration of treatment should not be exceeded. However, if a clear benefit has been demonstrated, continued therapy for a further three to four months period may be considered by the prescribing physician depending on the severity of the condition. In clinical studies, topical metronidazole therapy for rosacea has been continued for up to 2 years. In the absence of a clear clinical improvement, therapy should be stopped.

Adults: Metrogel should be applied in a thin layer to the affected areas of the skin twice daily, morning and evening. Areas to be treated should be washed with a mild cleanser before application. Patients may use non-comedogenic and non-astringent cosmetics after application of Metrogel.

Elderly: The dosage recommended in the elderly is the same as that recommended in adults.

Children: Not recommended. Safety and efficacy have not been established.

4.3 Contraindications

Contraindicated in individuals with a history of hypersensitivity to Metronidazole, or other ingredients of the formulation.

4.4 Special Warnings And Precautions For Use

Contact with mucous membranes should be avoided.

Metrogel has been reported to cause lacrimation of the eyes, therefore, contact with the eyes should be avoided. If a reaction suggesting local irritation occurs patients should be directed to use the medication less frequently or discontinue use temporarily and to seek medical advice if necessary. Metronidazole is a nitroimidazole and should be used with care in patients with evidence of, or history of, blood dyscrasia. Exposure of treated sites to ultraviolet (e.g. solarium, sun-lamp) or strong sunlight (including sun-bathing) should be avoided during use of metronidazole.

Unnecessary and prolonged use of this medication should be avoided.

Evidence suggests that metronidazole is carcinogenic in certain animal species. There is no evidence to date of a carcinogenic effect in human.

This product contains propylene glycol that may cause skin irritation and hydroxybenzoic acid esters which may cause allergic reactions (possibly delayed).

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Interaction with systemic medication is unlikely because absorption of metronidazole following cutaneous application of Metrogel is low. Nevertheless, it should be mentioned that disulfiram-like reactions have been reported in a small number of patients taking metronidazole and alcohol concomitantly. Oral metronidazole has been reported to potentiate the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin is not known. However, very rare cases of modification of the INR values have been reported with concomitant use of Metrogel and coumarin anticoagulants.

4.6 Pregnancy And Lactation

There has been no experience to date with the use of Metrogel in pregnant patients. In case of oral administration, metronidazole crosses the placental barrier and enters foetal circulation rapidly. No foetotoxicity was observed after oral metronidazole in either rats or mice. However because animal reproduction studies are not always predictive of human response and since oral metronidazole has been shown to be a carcinogen in some rodents this drug should be used in pregnancy only if clearly needed.

After oral administration metronidazole is secreted in breast milk in concentration similar to those found in plasma. Even though blood levels are significantly lower with cutaneous application of Metrogel than those achieved after oral metronidazole in nursing mothers, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into importance of the drug to the mother.

4.7 Effects On Ability To Drive And Use Machines

Based upon the pharmacodynamic profile and clinical experience performance related to driving and using machines should not be affected.

4.8 Undesirable Effects

Because of the minimal absorption of metronidazole and consequently its insignificant plasma concentration after topical administration, the adverse experiences reported with the oral form of the drug have not been reported with Metrogel. Adverse reactions reported with Metrogel have been only local and mild.

The following spontaneous adverse experiences have been reported, and within each system

organ class, are ranked by frequency, using the following convention:

Very common (

Common (

Uncommon (

Rare (

Very rare (<1/10,000), including isolated reports

Skin and subcutaneous tissue disorders:

Common: dry skin, erythema, pruritus, skin discomfort (burning, pain of skin/stinging), skin irritation, worsening of rosacea.

Unknown frequency: contact dermatitis

Nervous System disorders:

Uncommon: hypothesia, paraesthesia, dysgeusia (metallic taste)

Gastrointestinal disorders:

Uncommon: nausea

Watery eyes have been reported if applied too closely to this area.

4.9 Overdose

No data exists about overdosage in humans. Acute oral toxicity studies with a topical gel formulation containing 0.75% w/w metronidazole in rats have shown no toxic action with doses of up to 5 g of finished product per kilogram body weight, the highest dose used. This dose is equivalent to the oral intake of 12 tubes of 30g packaging Metrogel for an adult weighing 72 kg, and 2 tubes of Metrogel for a child weighing 12 kg.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

The etiology of rosacea is unknown although a variety of hypotheses have been reported.

5.2 Pharmacokinetic Properties

The systemic concentration of Metronidazole following the topical administration of 1 g of a 0.75% Metronidazole gel to 10 patients with rosacea ranged from 25 ng/ml (limit of detection), to 66 mg/ml with a mean Cmax of 40.6 ng/ml.

The corresponding mean Cmax following the oral administration of a solution containing 30 mg of metronidazole was 850 ng/ml (equivalent to 212 ng/ml if dose corrected. The mean Tmax for the topical formulation was 6.0 hours compared to 0.97 hours for the oral solution.

5.3 Preclinical Safety Data

Metronidazole is a well established pharmaceutical active ingredient and to the subject of pharmacopoeial monograph in both the BP and Ph.Eur.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Bronopol BP,

Hydroxybenzoic acid esters HSE,

Hydroxyethylcellulose HSE,

Propylene glycol Ph.Eur,

Phosphoric acid Ph.Eur,

Purified water Ph.Eur.

6.2 Incompatibilities

None known

6.3 Shelf Life

2 years.

6.4 Special Precautions For Storage

Store between 15°C and 25°C in a dry place.

6.5 Nature And Contents Of Container

Tube: Internally lacquered, membrane sealed aluminium.

Cap: low density polyethylene

Pack sizes available: 25 g and 40 g.

6.6 Special Precautions For Disposal And Other Handling

There are no special instructions for use/handling.

7. Marketing Authorisation Holder

Galderma (UK) Limited

Meridien House

69-71 Clarendon Road

Watford

Herts.

WD17 1DS

UK

8. Marketing Authorisation Number(S)

PL 10590/0035

9. Date Of First Authorisation/Renewal Of The Authorisation

27 February 1998

10. Date Of Revision Of The Text

December 2010

11 LEGAL CATEGORY

POM

Condylox Topical

Generic Name: podofilox (Topical route)

poe-DOF-il-lox

Commonly used brand name(s)

In the U.S.

• Condylox

In Canada

• Condyline

Available Dosage Forms:

• Gel/Jelly


• Solution

Therapeutic Class: Keratolytic

Uses For Condylox

Podofilox is used to remove certain types of warts on the outside skin of the genital areas (penis or vulva). The gel is used also to treat warts between the genitals and the rectum, the solution is not. Neither the gel nor the solution is used to treat warts that occur inside the rectum, vagina, or urine passageways inside the penis (male) or the vulva (female). Podofilox works by destroying the skin of the wart.

This medicine is available only with your doctor's prescription.

Before Using Condylox

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of podofilox in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of podofilox in the elderly with use in other age groups.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of podofilox

This section provides information on the proper use of a number of products that contain podofilox. It may not be specific to Condylox. Please read with care.

A paper with information for the patient will be given to you with your filled prescription and will provide many details concerning the use of podofilox. Read this paper carefully and ask your health care professional if you need additional information.

Also, keep podofilox away from the eyes and mucous membranes, such as the inside of the penis, rectum, or vagina. This medicine may cause severe irritation. If you get this medicine in your eyes or on one of these areas, immediately flush the area with water for 15 minutes.

Use podofilox only as directed, no more than 3 days a week and no more than 4 treatment cycles. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chances that this medicine is absorbed into the body and that side effects could occur.

Do not apply the medicine to any other wart until you discuss it with your doctor. The total dose of podofilox used on all warts should not exceed that which would cover an area measuring 1.6 square inches (10 square centimeters), about the size of a dollar coin.

To use:

• To apply the solution, use the applicators that come with the solution or a cotton-tipped applicator. To apply the gel, use a cotton-tipped applicator or your finger. Never reuse an applicator or dip a used applicator into the bottle.


• Apply podofilox only to the wart(s) discussed with your doctor.


• Podofilox can cause severe irritation of normal skin. If you get medicine on normal skin, wash it off immediately.


• Make sure the treated area is dry before allowing the treated skin to come in contact with normal, untreated skin.


• Immediately after applying this medicine, wash your hands to remove any medicine. Properly discard used applicator(s).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage form (gel):
  
  • For warts on penis or vulva (genitals) or on skin between genitals and rectum:
    
    • Adults—Apply to the wart(s) two times a day for three days in a row using an applicator tip or finger. Skip four days by not applying any medicine for four days in a row. If the wart can still be seen, this application cycle may be repeated each week for up to four weeks, until the wart is gone. No more than 0.5 grams of gel should be used each day of treatment.
    
    
    • Children—Use and dose must be determined by the doctor.
    
    
  
  


• For topical dosage form (solution):
  
  • For warts on penis or vulva (genitals) only:
    
    • Adults—Apply to the wart(s) two times a day (every twelve hours) for three days in a row using applicator tip. Skip four days by not applying any medicine for four days in a row. If the wart can still be seen, this application cycle may be repeated each week for up to four weeks, until the wart is gone. No more than 0.5 milliliters of solution should be used each day of treatment.
    
    
    • Children—Use and dose must be determined by the doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Condylox

Podofilox may not be able to prevent previously healed warts from reappearing or stop new warts from growing.

This medicine contains alcohol and therefore may be flammable. Do not use near heat, near open flame, or while smoking.

Condylox Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Bad odor (solution only)


• bleeding of treated skin


• blistering, crusting, or scabbing of treated skin


• bloody urine (solution only)


• burning feeling of treated skin


• dizziness (solution only)


• headache (gel only)


• itching of treated skin


• pain during sexual intercourse (solution only)


• pain of treated skin


• problems with foreskin of penis (solution only)


• redness or swelling of treated skin


• scarring of treated skin (solution only)


• skin ulcers of treated skin


• vomiting (solution only)

Symptoms of overdose - in order of occurrence

• Nausea


• vomiting


• diarrhea


• chills


• fever


• sore throat


• unusual bleeding or bruising


• oral ulcers

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Dryness of treated skin


• peeling of treated skin


• soreness or tenderness of treated skin


• stinging or tingling of treated skin


• trouble in sleeping (solution only)

Less common

• Changes in color of treated skin (gel only)


• skin rash (gel only)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Condylox Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Condylox Topical resources

• Condylox Topical Side Effects (in more detail)
• Condylox Topical Use in Pregnancy & Breastfeeding
• Condylox Topical Support Group
• 3 Reviews for Condylox Topical - Add your own review/rating

Compare Condylox Topical with other medications

• Condylomata Acuminata

Mydral Ophthalmic

Generic Name: tropicamide (Ophthalmic route)

troe-PIK-a-mide

Commonly used brand name(s)

In the U.S.

• Mydral


• Mydriacyl


• Ocu-Tropic


• Tropicacyl

Available Dosage Forms:

• Solution

Therapeutic Class: Mydriatic-Cycloplegic

Pharmacologic Class: Antimuscarinic

Uses For Mydral

Tropicamide is used to dilate (enlarge) the pupil so that the doctor can see into the back of your eye. It is used before eye examinations, such as cycloplegic refraction and examination of the fundus of the eye. Tropicamide may also be used before and after eye surgery.

This medicine is available only with your doctor's prescription.

Before Using Mydral

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Infants and young children and children with blond hair or blue eyes may be especially sensitive to the effects of tropicamide. This may increase the chance or severity of some of the side effects during treatment.

Geriatric

Elderly people are especially sensitive to the effects of tropicamide. This may increase the chance of side effects during treatment.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain damage (in children) or


• Down's syndrome (mongolism) (in children and adults) or


• Glaucoma or


• Spastic paralysis (in children)—Tropicamide may make the condition worse

Proper Use of tropicamide

This section provides information on the proper use of a number of products that contain tropicamide. It may not be specific to Mydral. Please read with care.

To use:

• First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 2 or 3 minutes to allow the medicine to be absorbed by the eye. This is especially important in infants.


• Immediately after using the eye drops, wash your hands to remove any medicine that may be on them. If you are using the eye drops for an infant or child, be sure to wash the infant's or child's hands also, and do not let any of the medicine get in the infant's or child's mouth.


• To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For ophthalmic solution (eye drops) dosage form:
  
  • For cycloplegic refraction (eye examination):
    
    • Adults—One drop of 1% solution, repeated once in five minutes.
    
    
    • Children—One drop of 0.5 to 1% solution, repeated once in five minutes.
    
    
  
  
  • For examination of fundus of eye:
    
    • Adults and children—One drop of 0.5% solution fifteen to twenty minutes before examination.
    
    
  
  

Precautions While Using Mydral

After this medicine is applied to your eyes:

• Your pupils will become unusually large and you will have blurring of vision, especially for close objects. Make sure your vision is clear before you drive, use machines, or do anything else that could be dangerous if you are not able to see well.


• Your eyes will become more sensitive to light than they are normally. When you go out during the daylight hours, even on cloudy days, wear sunglasses that block ultraviolet (UV) light to protect your eyes from sunlight and other bright lights. Ordinary sunglasses may not protect your eyes. If you have any questions about the kind of sunglasses to wear, check with your doctor.


• If these effects continue for longer than 24 hours after the medicine is used, check with your doctor.

Mydral Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Symptoms of too much medicine being absorbed into the body

• Clumsiness or unsteadiness


• confusion


• fast heartbeat


• flushing or redness of face


• hallucinations (seeing, hearing, or feeling things that are not there)


• increased thirst or dryness of mouth


• skin rash


• slurred speech


• swollen stomach in infants


• unusual behavior, especially in children


• unusual drowsiness, tiredness, or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blurred vision


• headache


• sensitivity of eyes to light


• stinging of the eye when the medicine is applied

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Mydral Ophthalmic side effects (in more detail)

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More Mydral Ophthalmic resources

• Mydral Ophthalmic Side Effects (in more detail)
• Mydral Ophthalmic Use in Pregnancy & Breastfeeding
• Mydral Ophthalmic Drug Interactions
• Mydral Ophthalmic Support Group
• 0 Reviews for Mydral Ophthalmic - Add your own review/rating

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